P2Y12 receptor Mutagenesis

Amino Acid Sequence Alignment of P2Y12 species

Evolutionary constraints of the P2Y12 receptor family - Follow the link to view the sequence variation within the P2Y12 receptor family mapped onto a 3-D homology model

Receptor
hP2Y12
Dasypus_novemcinctus
Loxodonta_africana
Bos_taurus
Equus_caballus
Sus_scrofa
Myotis_lucifugus
Pteropus-vampyrus
Canis_familiaris
Felis_catus
Choloepus_hoffmanni
Echinops_telfairi
Erinaceus_europaeus
Monodelphis_domestica
Ornithorhynchus_anatinus
Trichosurus-vulpecula
Callithrix_jacchus
Macaca_fascicularis
Macaca_mulatta
Microcebus_murinus
Otolemur_garnettii
Pan_troglodytes
Pongo_pygmaeus
Tarsius_syrichta
Dipodomys_ordii
Cavia_porcellus
Mus_macedonicus
Mus_mullissinus
Mus_musculus
Mus_spretus
Ochotona_princeps
Oryctolagus_cuniculus
Rattus_norvegicus
Spermophilus_tridecemline
Tursiops_truncatus
Gallus_gallus
Anolis_carolinensis
Osmerus-mordax
Xenopus_tropicalis
Danio-rerio
Gasterosteus-aculeatus
Oryzias-latipes
Takifugu_rubripes
Tetraodon_nigroviridis
Callorhinchus_milii
Consensus
Receptor

TMH1ICL1TMH2ECL1TMH3ICL2TMH4ECL2TMH5ICL3TMH6ECL3TMH7Helix8
-------------------------------------------M Q A V D N L T S A P G N T S --L C T R D Y K I TQVLFPLLYTVLFFVGLITNGLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P KNLLGAKILSVVIWAFMFLLSLPNMIL T N R Q P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C T A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P N S A T S L S --Q D N R K K E Q D G G D P N E E T P M ------------
-------------------------------------------M Q V I K N L T A A A G N G S --L C T R N Y K I TQVLFPLLYTVLFFVGLITNCLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RAFVCQVTSVTFYFTMYISISFLGLITIDRYQKTTRP F K S F H P NNLWGAKILSXVIWVFMFFLSLPNMIL T N R R P T D K -N V E K C S F L K S E F G L VWHEIVNYICQVIFWINFLIIVVCYTLIT K E L Y R S Y V R T R G P -----------------G K VPRKRVSIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLMSRLK C P N S A T S P S --Q E N K K R G L N G G D P D E E T P M ------------
----------------------------------------------M D N L T I A A G N S S --L C T R D Y K I NQVLFPLLYTVLFFIGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAELGT G S L RAFVCQVTSVVFYFTMYISISFLGLITIDRYQRTTRP F K T L K P NNLLGAKVLSVVIWAFMFLLSLPNMIL T N K R P R D K -N V K K C S F L K S E F G L VWHEMVNYICQVIF-INFLIIIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPKKKVNIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMSMLK C S N S A T F P A --Q E Q R K E G Q N S G T P S L E T P M ------------
----------------------------------------------M D N L T S V A G N S S --Q C S R D Y K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDTKLGT G P L RAFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F K T A N P NNLLGAKILSVVIWAFMFLISLPNMIL T N R R P S D K -T V K K C S F L K S E F G L VWHEIVNYVCQVIFWINFLIVIVCYTLIT K E L Y K S Y V R T R G A -----------------G K VPKKKVNIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C T A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMSMLR C S N S T S P P S --H D N R K K G Q D G S D P S E E T P M ------------
----------------------------------------------M D N L T S V A R N S S --L C T R D Y K I TQVLFPLLYTLLFFVGLIINSLAMRVFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F K T S N P NNLLGAKILSVVIWAFMFLLSLPNMIL T N K R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G T -----------------G K APRKRVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C P A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKHSLMAMLK C P N S A T S P A --P E N R R K A Q A G G D P S E E T P M ------------
----------------------------------------------M E N L T S A P G N G S --L C I R D Y K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RAFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P NNLLGAKILSVVIWAFMFLLSLPNMIL T N R R P S D --N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y K S Y V R T R G V -----------------G K VPKKKVNIKVFIIIAVFLICFVPFHFARIPYTLSQ T R -D V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMSMLK C S N S A S S P X --X R N R K K G Q D G D D P S E E T P M ------------
----------------------------------------------M D N F T S P P G N G S --L C T R D Y H I TQVLFPLLYTVLFFTGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RVFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S S P NNLLGAKILSVVIWAFMFLLSLPNMIL T N R R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G T -----------------G K VHKKKVNIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F N C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMSMLK C T N S A T S P ---H E N R G K G Q D G R D P S E E T P I ------------
----------------------------------------------M D N L T S A A G N G S --L C I R D Y K I TQVLFPLLYTVLFFTGLITNSLAMRIFFQIR S KSNFIIFLKNTVIXDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVTFYFTMYISISFLGLITIDRYQKTTRP F K T S N P NNLLGAKILSVVIWAFMFLLSLPNMIL T N R R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMSMLK C P N S A A S P P --H E N R K K G Q N D G D P S E E T P M ------------
----------------------------------------------M D N L T S V A G N G S --L C T R D Y K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F K T S S P NNLLGAKILSVVIWAFMFLLSLPNMIL T N R R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPKKKVNIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMNMLK C Q N P A T S L S --H E N R K K E Q D G G D P N E E T P M ------------
----------------------------------------------M D N L T S V A G N G S --L C T R D Y K I TQVLFPLLYTVLFFVGLIINSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILXFPFKILSDTKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P NNLLGAKILSVVIWAFMFLISLPNMIL T N R R P R E K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMSMLK C P N S A T S L S --Q E N R K K E Q D G G D P S E E T P M ------------
-------------------------------------------M Q V I D N F T A A D G N G S --R C T R D Y K I TQVLFPLLYIVLFFVGLITNCLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAELGT G S L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F N T S S P NNLLGAKILSVVIWVFMFLLSLPNMIL T N R K P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIIIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C S A E N TLFYMKESTLWLTSLNACLDPFIYFF LCKSFRNSLITRLK C T N S A T S P T --H G N K K K G Q N G G D P D E E -P M ------------
-----------------M C L R R H P Q L P G P K S N S L T S L L P A A P E Q A D I D N V T A G A A A G N S S L C A R H D K I THVLFPLLYTVLFFTGLVTNSLAMKIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAELG--S L RALVCQVTSVVFYFDMYISISFLGLITVDRYQKTTRP F T T A S S SRLLGAKVLSGVIGAFMFFLALPNMIL T N X R P T D A -S V K K C S F L X S E F G L VWHEIVNYICQVIFWINFXIIVVCYTLIT X E L Y R S Y V R A R G A -----------------G K VPRKRVNIRVFIIIAVFFVCFVPFHFARIPYTLSQ T R -E V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLMSMLR C S K P V T P P D --Q G T R N K G Q N G S D P S E E T P L ------------
M S L K P P L S E V P V P L K G Y A D R Q Q Q N L G L Q V T L C L L S L P V G G K Q Q P W A M E N L T S A S G N G S --S C S R D Y K I TQVLFPLLYTILFFVGLITNSLAMRIFFQIQ S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RAFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T A N P KNLLGAKILSVVIWAFMFLLSLPNMIL T N R R P K D K -N V N K C S F L K S E F G L VWHEIVNYICQVIXXINFXSVTVCYTLIT T E L Y R S Y V R T R G T -----------------G K APLKKXNIRXFIIIAVSSVXFVPFHFARIPYTLSQ T R -D V F N C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFKNSLMSMLT C S D S A T S P S S S Q E K R R K A P D S P E P S E E T P I ------------
-------------------------------------------M S D F D N F T N G T G N H S --L C T R D Y K I TQVLFPLLYTVLFVVGITMNSLAMGIFFQIP S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA G P L RAFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N L NNPLGAKILSAVIWIFMFLLSLPNMIL T N K K P V H L -N V K K C A F L K S D F G L VWHEIVNYICQVIFWINLLIIIVCYTLIT K E L Y R S Y V R T R G V -----------------G K APKKTVNVKVFIVIAVFFICFVPFHFARIPYTLSQ T R -D V F D C T A E N TLFYVKESTLWLTSLNACLDPFIYFY LCKSFRNSLMSMLR H R N A P -I A S -A Q E I R N K G Q D N S S P S E E I P L ------------
-------------------------------------------M R V S H N F T Q A P G N G S S -I C S R D Y K I TQVLFPVLYTVLFFVGIVMNGLAMRIFFQIP S KSNFIIFLKNTVISDLFMILTFPFKILSDAKLGP G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K A A G L NNLLGTKILSVVIWAFMFLLSLPNMIL T N N K P L R A -N V K K C S F L K S E F G L VWHEIVNYVCQVIFWINLVIIIVCYVLIT K E L Y R S Y V R T R G V -----------------G K VPRKTVNMKVFIVIAVFFTCFVPFHFARIPYTLSQ T R D D V F D C S A E N TLFYIKESTLWLTSLNACLDPFIYFF LCKSFRNSLKAMLK R P N D L T F S H --E E M K N K R Q E S S T P S E E T P I ------------
-------------------------------------------M S D L Y N F T N G T G N Y S --L C T R D Y K I TQVLFPLLYTVLFVVGIIMNSLAMGIFFQIP S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA G P L RAFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N L NNLLGAKILSAVIWIFMFLLSLPNMIL T N K K P G H S -N V K K C A F L K S E F G L VWHEIVNYICQVIFWINLLIIIVRYTLIT K E L Y R S Y V R T R G V -----------------G K APKKKVNIKVFIVIAVFFICFVPFHFARIPYTLSQ T R -D V F D C T A E N TLFYVKESTLWLTSLNACLDPFIYFY LCKSFRNSLMGMLR H R N A P T M F S -P Q E I R N K G Q D N S S P S E D I P L ------------
-------------------------------------------M Q A I D N L T S V P G N T S --L C T R D Y K I TQVLFPLLYTILFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P KNLLGAKILSVVIWAFMFLLSLPNMIL T N R Q P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT N E L Y R S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C A A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P N T A A S L S --Q -N R E K K Q H G G D L N E E T P M ------------
-------------------------------------------M Q A I D N L T S A P G N T S --L C T R D Y K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P KNLLGAKILSVLIWAFMFLLSLPNMIL T N R R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C A A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P N S A T S Q S --Q D N R K K E Q D G G D P N E E T P M ------------
-------------------------------------------M Q A I D N L T S A P G N T S --L C T R D Y K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P KNLLGAKILSVLIWAFMFLLSLPNMIL T N R R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C A A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P N S A T S Q S --Q D N R K K E Q D G G D P N E E T P M ------------
-------------------------------------------M Q A L D N L T S V P G N G S --L C T R D Y K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P SNLLGAKILSVVIWAFMFLLSLPNMIL T N R R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y K S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C A A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMVK C P S S A T S S S --Q E N R K K G Q N G G D T S E E T P M ------------
-------------------------------------------M Q A I N N L T S E P G N S S --L C T R D H K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F Q T A N P SNLLGAKILSVLIWAFMFFISLPNMIL T N R R P R D K -N V N K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y I R T R G A -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C A A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P N S A T S -S --Q E N R K K G Q N S D D P R E E T P M ------------
-------------------------------------------M Q A V D N L T S A P G N T S --L C T R D Y K I TQVLFPLLYTVLFFVGLITNGLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N P KNLLGAKILSVVIWAFMFLLSLPNMIL T N R Q P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVTVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C T A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P N S A T S L S --Q D N R K K E Q D G G D P N E E T P M ------------
-------------------------------------------M Q A I D N L T S A P G N T S --L C T R D Y K I TQVLFTLLYTVLFFVGLITNGLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T S N L KNLLGAKILSVVIWAFMFLLSLPNMIL T N R Q P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C T A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P N S A T S L S --Q D N R K K E Q D G G D P N E E T P M ------------
-------------------------------------------M Q V T D N L T S V P G N N S --L C T R D Y K I TQVLFPLLYTVLFFVGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F Q T S N P SNLLGAKILSVVIWAFMFLLSLPNMIL T N R R P R D K -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y V R X R G P -----------------G K VPREKVNVKVFIIIAVFLICVVPFHFARIPYTLSQ T R -D V F D C I A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLITMLK C P N S A T P S S --Q E N R K K E Q D G S D P S E X T P M ------------
-------------------------------------------M Q A L A N V T P A P G N S S --Q C S R D Y A I AEALFPLLYTGLFFVGLITNSLAMRIFFQIN S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGP R P L RAFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F H T S S P RNLLGAKILSAVIWAFMFLLSLPNMIL T N R R P R D I -H V K K C S F F K S E F G L VWHEIVNYVCQVIFWINFFIVIVCYTLIT K E L Y R S H V R T R A V -----------------G K VPRKRVSVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C A S E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLTGMLK C P K S R T S L S --R E N R K K G P D G S D P -E E T P M ------------
-------------------------------------------M -A T S N L T S E P G N S S --L C A R D Y K I TQILFPLLYTVLFFVGLITNSLAMRIFFQIN S KSNFIIFLKNTVISDLLMILTFPFKILSDAELGP G P L RTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRP F K T T N P SNLLGAKILSVVIWAFMFLFSLPNMIL T N R R P P G K -I V K K C S F F K S Q F G L VWHEIVNYICQVIFWINFLIIIVCYTLIT K E L Y R S Y V R T R G V -----------------G K VPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C A A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLR C H N S E K S S S --Q E N R K K R Q D N S D P S E E T P M ------------
-------------------------------------M D V P G V N T T S A N T T F S P G T S T --L C V R D Y K I TQVLFPLLYTVLFFAGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA G P L RTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRP F K T S S P SNLLGAKILSVVIWAFMFLISLPNMIL T N R R P K D K -D V T K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYSLIT K E L Y R S Y V R T R G S -----------------A K VPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -A V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLTSMLR C S N S T S T S ---G A N K K K G Q E G G E P S E E T P M ------------
-------------------------------------M D V P G V N T T S A N T T F S P G T S T --L C V R D Y K I TQVLFPLLYTVLFFAGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA G P L RTLVCQVTSXTFYFTMYISISFLGLITIDRYLKTTRP F K T S S P SNLLGAKILSVVIWAFMFLISLPNMIL T N R R P K D K -D V T K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYSLIT K E L Y R S Y V R T R G S -----------------A K VPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -A V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLTSMLR C S N S T S T S ---G T N K K K G Q E G G E P S E E T P M ------------
-------------------------------------M D M P G V N T T S A N T T F S P G T S T --L C V R D Y K I TQVLFPLLYTVLFFAGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA G P L RTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRP F K T S S P SNLLGAKILSVVIWAFMFLISLPNMIL T N R R P K D K -D V T K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYSLIT K E L Y R S Y V R T R G S -----------------A K VPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -A V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLTSMLR C S N S T S T S ---G T N K K K G Q E G G E P S E E T P M ------------
-------------------------------------M D V P V V N T T S A N T T F S P G T S T --L C V R D Y K I TQVLFPLLYTVLFFAGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA R P L RTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRP F K T S S P SNLLGAKILSVVIWAFMFLISLPNMIL T N R R P K D K -D V T K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYSLIT K E L Y R S Y V R T R G S -----------------A K VPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -A V F D C S A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLTSMLR C S N S T S T S ---G A N K K K G Q E G G E P S E E T P M ------------
-------------------------------------------M P A I D N L T A G P R N S S --L C T R D Y K I TQVLFPLLYTVLFFTGLITNGLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L R-FVCRXTSVIFYFTMYISISFLGLITIDRYQKTTQP F R T S N S TSLLGAKILSAVIWAFMFLLSLPNMIL T N K R P R D S -N E K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y K S Y L R T K G V -----------------G K VPRKKVNGKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F N C T A E N ALFYLKESTLWLTSLNACLDPFIYFF PLQVLQKFPDKHAE V S Q L C V T Y -----I P R K E E K G T G W ------------------
-------------------------------------------M Q A T D N L T S V P G N S S --V C A R D Y K I TQVLFPLLYTLLFVTGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGT G P L RTFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F K T S N P TNLLGAKILSVAIWAFMFLLSLPNMIL T N K R P R N T -N V K K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYTLIT K E L Y K S Y V R T R G A -----------------G K APRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQ T R -D V F D C T A E N ALFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLMSMMK Y P N S A T S P S --Q E N R K K G Q D G G D P S E E T P M ------------
-------------------------------------M E V P G A N A T S A N T T S I P G T S T --L C S R D Y K I TQVLFPLLYTVLFFAGLITNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGA G H L RTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRP F K T S S P SNLLGAKILSVAIWAFMFLLSLPNMIL T N R R P K D K -D I T K C S F L K S E F G L VWHEIVNYICQVIFWINFLIVIVCYSLIT K E L Y R S Y V R T R G S -----------------A K APKKRVNIKVFIIIAVFFICFVPFHFARIPYTLSQ T R -A V F D C N A E N TLFYVKESTLWLTSLNACLDPFIYFF LCKSFRNSLMSMLR C S T S G A N -------K K K G Q E G G D P S E E T P M ------------
-------------------------------------------M L L S E N F T L A P G N S S --M C A R N Y K I TQVLFPLLYTVLFFVGLVTNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGP G P L RTFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F K T S S P QSLLGAKVLSVVIWAFMFLLSLPNMIL T N R R P R D K -S I K K C S F L K S E F G L VWHEITNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y M R T R G S -----------------S K APRKKVNVRVFIVIAVFFLCFVPFHFARIPYTLSQ T R -E V F D C A A Q N TLFYLKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P S S A M A P S --R G D K K K A E G A G D P S E E T P M ------------
-------------------------------------------M L L S E N F T L A P G N S S --M C A R N Y K I TQVLFPLLYTVLFFVGLVTNSLAMRIFFQIR S KSNFIIFLKNTVISDLLMILTFPFKILSDAKLGP G P L RTFVCQVTSVVFYFTMYISISFLGLITIDRYQKTTRP F K T S S P QSLLGAKVLSVVIWAFMFLLSLPNMIL T N R R P R D K -S I K K C S F L K S E F G L VWHEITNYICQVIFWINFLIVIVCYTLIT K E L Y R S Y M R T R G S -----------------S K APRKKVNVRVFIVIAVFFLCFVPFHFARIPYTLSQ T R -E V F D C A A Q N TLFYLKESTLWLTSLNACLDPFIYFF LCKSFRNSLISMLK C P S S A M A P S --R G D K K K A E G A G D P S E E T P M ------------
------------------------------------------M Q T K A T S N F S Y S I N G S --N C T S D N R I RQVIFPLLYTLLFLVGLTMNGLAMWVFFKIS S KSNFIIFLKNTVISDILMILTFPFKILSDAQLVP W V L RGFVCQVSQVVFYFTMYISILFLGLITIDRYQKATSP F R T S T T RSLLGAKILSTAIWILMFILSLPNMIL T N K K K T P T -N V K K C A L L K S E F G L VWHEAVNYICQLIFWVNLIVIVVCYILIS K E L Y K S Y Q R T R C T -----------------G R PSRKSVNLKVFIIIAVFFICFVPFHFTRIPYTLSQ T R -N V F D C S A V N TLFYLKESTLWLTSLNACLDPFIYFF LCKSFRKSLLGMLC K H T A S P E ----L Q A Q I A V Q N E R D D T E D T P V ------------
----------------------------------------------M D P G Y S P S G N G S --N C S T D K S M NQVLFPLLYTFIFVVGIIMNGLAMGVFFQIA N KSNFIIFLKNTVIADILMILTFPFKILSDAKLVS W