P2Y12 receptor Mutagenesis

In order to achieve a transparent application of the sequence numbering we implemented different sequence numbering schemes. To facilitate analysis of the comparative relationship between the receptors, a widely spread GPCR residue indexing system is also offered

• The sequence numbering for each specific GPHR separately, including the signal peptide (No)
• The Ballesteros-Weinstein (Ba-We) nomenclature (Ballesteros JA, Weinstein H, Methods Neurosci. 1995, 25, 366-428) for amino acids of transmembrane helices (TMHs). A highly conserved residue at each helix, is used as a reference common for all GPCRs at family A. For example, the highly conserved Asn at TMH1 is defined as 1.50 and the highly conserved Pro from the NPxxY motif of TMH7 is defined as 7.50.